Immunosuppression by ochratoxin A and its prevention by phenylalanine.
نویسندگان
چکیده
Ochratoxin A, a toxin of Aspergillus ochraceus, suppresses the immune response to sheep erythrocytes in BALB/c mice at doses as low as 0.005 microgram/kg of body weight. This effect is prevented by phenylalanine.
منابع مشابه
Ochratoxin A Producing Fungi, Biosynthetic Pathway and Regulatory Mechanisms
Ochratoxin A (OTA), mainly produced by Aspergillus and Penicillum species, is one of the most important mycotoxin contaminants in agricultural products. It is detrimental to human health because of its nephrotoxicity, hepatotoxicity, carcinogenicity, teratogenicity, and immunosuppression. OTA structurally consists of adihydrocoumarin moiety linked with l-phenylalanine via an amide bond. OTA bio...
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عنوان ژورنال:
- Applied and environmental microbiology
دوره 41 4 شماره
صفحات -
تاریخ انتشار 1981